Jon Gets Schizo
Here are a couple of different links along the same line of thought.
What if the Garfield comic strip did away with Garfield's speech bubbles? You'd get a portrait of a man who talks to his cat without getting a response.
Garfield Without Speech Bubbles
What if you removed Garfield altogether? You get an even more disturbing comic strip about a man with serious mental health issues.
Garfield Without Garfield